Adipose-derived Stem Cells vs. Umbilical cord Stems for Telomerase Enhancement
Adipose-Derived Stem Cells vs. Umbilical-Derived Stem Cells: Telomerase
Activity
By Alvin Mendieta
Telomerase Activity in Adipose-Derived Stem Cells (ADSCs):
Adipose-derived stem cells (ADSCs) exhibit notable telomerase activity, which
contributes to their regenerative capacity and survival after implantation. This activity is
crucial for maintaining telomere length, allowing ADSCs to proliferate extensively and
differentiate into various cell types[1][4][6].
Comparison with Umbilical-Derived Stem Cells (USCs):
In contrast, umbilical-derived stem cells generally show lower telomerase activity. This
reduced activity may limit their proliferation and differentiation potential compared to
ADSCs[2][3]. The higher telomerase activity in ADSCs supports their enhanced survival
and ability to replicate and differentiate into multiple stem cell types, making them a
valuable resource for regenerative medicine[5][8].
References:
[1] Telomere Length and Telomerase Activity in Subcutaneous ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818289/
[2] Telomere and telomerase in stem cells | British Journal of Cancer
https://www.nature.com/articles/6603671
[3] Differentiation Capacity of Human Urine-Derived Stem Cells to ...
https://www.frontiersin.org/journals/cell-and-developmental-
biology/articles/10.3389/fcell.2022.890574/full
[4] Telomeres and Telomerase in the Control of Stem Cells - PMC - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598777/
[5] Human mesenchymal stem cells with enhanced telomerase activity ...
https://www.sciencedirect.com/science/article/abs/pii/S1465324917305418
[6] Application of telomere biology and telomerase in mesenchymal ...
https://www.sciencedirect.com/science/article/pii/S2790676023000250
[7] Myocardin A Enhances Telomerase Activities in Adipose Tissue ...
https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdf/10.1634/stemcells.2007-0490
[8] Adipose-Derived Mesenchymal Stromal Cells From Aged Patients ...
https://academic.oup.com/stcltm/article/3/1/32/6388007